Synthesis of organometallic PNA oligomers by click chemistry.
نویسندگان
چکیده
The facile side-specific insertion, on the solid phase, of one or two ferrocene moieties into peptide nucleic acid (PNA) oligomers by click chemistry is presented.
منابع مشابه
"Four-potential" ferrocene labeling of PNA oligomers via click chemistry.
The scope of the Cu(I)-catalyzed [2 + 3] azide/alkyne cycloaddition (CuAAC, click chemistry) as a key reaction for the conjugation of ferrocene derivatives to N-terminal functionalized PNA oligomers is explored herein (PNA: peptide nucleic acid). The facile solid-phase synthesis of N-terminal azide or alkyne-functionalized PNA oligomer precursors and their cycloaddition with azidoferrocene, eth...
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ورودعنوان ژورنال:
- Chemical communications
دوره 31 شماره
صفحات -
تاریخ انتشار 2008